Endocrine Abstracts

Introduction: Measurement of copeptin is proposed for use in the differential diagnosis of polyuric syndrome.Aims: To evaluate the diagnostic value of copeptin levels in patients with polyuria syndrome.Materials and methods: The study included 17 patients with central diabetes insipidus (CDI), 3 patients with nephrogenic diabetes insipidus (NDI), 7 patients with primary polydipsia (PP) and 26 control subjects. In all individuals bl...

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

Introduction: Patients with resistant prolactinomas have reduced fertility todue to chronic anovulation and hypoplasia of uterus and ovaries. SERM tamoxifen demonstrates a recovery of menstrual function and ovulation and reverses the hypoplasia of the uterus. The mechanism of its action in case of hyperprolactinemia is not clear yet.Aim: To study the role of kisspeptin in restoration of reproductive function in patients with prolactinomas treated by tamo...

Introduction: Acromegaly impairs the hypothalamic-pituitary-gonadal (HPG) axis and reproductive function that causes amenorrhea and infertility. The mechanism of these disturbances is not clear. Kisspeptin and neurokinin B are very important neuropeptides regulating cyclic LH release from pituitary due to stimulation of GnRH.Aim: The purpose of this study was to assess the role of key reproductive neuropeptides in regulation of menstrual function in pati...

Background: In most cases of parathyroid carcinoma (PC) only recurrence could be a credible feature of malignancy.Clinical case: At the age of 19 years a woman was diagnosed with urolithiasis. At the age of 22 years she had a surgical resection of the neck nodule at the right site in the projection of carotid triangle. After the histological study, ectopic parathyroid tumor was misdiagnosis with paraganglioma (material is available for review). At the ag...

Introduction: In recent years, more attention is driven to the cause of hereditary forms of pituitary adenomas. Although for most cases causal genes are not discovered yet, AIP mutations are the most prevalent.Materials and Methods: Case descriptions, high-parallel sequencing using a gene panel (MEN1, CDKN1B, PRKAR1A, GNAS, AIP, SDHA, SDHB, SDHS, SDHD, PRKCA, CDKN2C, CDKN2A, POU1F1, PTTG2).Case description: Index ...

Introduction: Most of the work on the analysis of molecular genetic defects in pituitary adenomas devoted to the study of 1–2 candidate genes. The high-performance parallel sequencing is more promising.Materials and Methods: There were a total of 26 families (58 patients, 36 (62.1%) men and 22 (37.9%) women) with pituitary adenomas secretion of various types. The number of families with homogenous type was 17 (somatotropinomas 13, prolactinomas 2, c...

Introduction: Medical therapy with dopamine agonists is the best treatment for prolactinomas of any size or invasiveness and restores ovulatory cycles in 80–90% of patients. Cabergoline currently suggested nearly exclusively rather than other dopamine agonists due to its excellent tolerability and long half-life. That is why the question of safety using of this drug during pregnancy and embryo-fetal development is actual.Aim: The aim of the study is...

Introduction: The improvement of vitamin D status is necessary to overcome an impaired calcium-phosphorus metabolism and disturbances in other tissues functioning; safety of medical intervention should include analysis of metabolic changes.Material and methods: Twenty four apparently healthy volunteers 24.9±2 year were included in the study: Group 1 (11/24) with blood serum levels of 25(OH)D <10 ng/ml and Group 2 (13/24) with 25(OH)D levels 10&#...

Introduction: Somatotropinomas are typically recognized when GH excessively secretion causes acromegaly. «Silent» somatotroph adenomas (immunohistochemical evidence of GH excess without biochemical or clinical evidence) and «clinically silent» somatotroph adenomas (immunohistochemical and biochemical evidence without clinical evidence) have occasionally been reported. The relative frequency of each presentation is unknown.<p class="abst...